Tumor necrosis factor-α and osterix expression after the transplantation of a hydroxyapatite scaffold from crab shell (Portunus pelagicus) in the post-extraction socket of Cavia cobaya

Background: Socket preservation using bone graft is one way to minimise resorption and maximise the formation process. Tumor necrosis factor-α (TNF-α) an inflammatory cytokine that affects regenerating osteoblast activity, while osterix (Osx) osteoblast-specific transcription factor activates gene receptors during pre-osteoblast differentiation. The hydroxyapatite (HA) scaffold from crab shells (Portunus pelagicus) has osteoconduction properties. Purpose: To analyse decrease of TNF-α expression increase Osx correlation between these two in post-extraction socket after transplantation a shell HA scaffold. Methods: lower left incisors Cavia cobaya (n = 24) were extracted divided into four groups: first second groups control on Day 7 14 (K7 K14), third fourth treatment (P7 P14). statistical analysis used was multivariate variance (MANOVA) with significance level 0.05. Results: A MANOVA test showed use scaffolds led significant difference (p < 0.05) 0.01) 0.01). Pearson result strong inverse expressions 0.00 r -0.78). Conclusion: can but C. cobayas. Furthermore, found Osx.